Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal,
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

Formins are a widely expressed family of proteins that govern cell shape, adhesion,
cytokinesis, and morphogenesis by remodeling the actin and microtubule cytoskeletons …

Oncosomes have recently been described as membrane-derived microvesicles secreted by
cancer cells, which transfer oncogenic signals and protein complexes across cell …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …

Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

Formin proteins are potent regulators of actin dynamics. Most eukaryotes have multiple
formin isoforms, suggesting diverse cellular roles. Formins are modular proteins, containing …

Autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney
disease are the best known of a large family of inherited diseases characterized by the …

The past decade or so has seen rapid progress in our understanding of how left-right (LR)
asymmetry is generated in vertebrate embryos. However, many important questions about …