Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

K Mitusova, OO Peltek, TE Karpov… - Journal of …, 2022 - Springer
Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria

R Yang, F Mele, L Worley, D Langlais, J Rosain… - Cell, 2020 - cell.com
Inborn errors of human interferon gamma (IFN-γ) immunity underlie mycobacterial disease.
We report a patient with mycobacterial disease due to inherited deficiency of the …

Immunological aspects of rabies: a literature review

ISS Katz, F Guedes, ER Fernandes… - Archives of …, 2017 - Springer
Rabies is a lethal disease caused by the neurotropic virus rabies virus (RABV), and it
remains an important public health problem globally. It is known that the host immune …

mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism

KE Mastraccio, C Huaman, SAA Coggins… - EMBO Molecular …, 2023 - embopress.org
Infections with rabies virus (RABV) and related lyssaviruses are uniformly fatal once virus
accesses the central nervous system (CNS) and causes disease signs. Current …

A single vaccination of nucleoside-modified Rabies mRNA vaccine induces prolonged highly protective immune responses in mice

S Bai, T Yang, C Zhu, M Feng, L Zhang… - Frontiers in …, 2023 - frontiersin.org
Background Rabies is a lethal zoonotic disease that kills approximately 60,000 people each
year. Although inactivated rabies vaccines are available, multiple-dose regimensare …

An mRNA-based rabies vaccine induces strong protective immune responses in mice and dogs

J Li, Q Liu, J Liu, X Wu, Y Lei, S Li, D Zhao, Z Li, L Luo… - Virology Journal, 2022 - Springer
Rabies is a lethal zoonotic disease that is mainly caused by the rabies virus (RABV).
Although effective vaccines have long existed, current vaccines take both time and cost to …

Characterisation of a Live-Attenuated Rabies Virus Expressing a Secreted scFv for the Treatment of Rabies

SP Smith, R Shipley, P Drake, AR Fooks, J Ma… - Viruses, 2023 - mdpi.com
Rabies virus (RABV) causes possibly the oldest disease and is responsible for an
estimated> 59,000 human fatalities/year. Post exposure prophylaxis (PEP), the …

Colloidal manganese salt improves the efficacy of rabies vaccines in mice, cats, and dogs

Z Wang, Y Yuan, C Chen, C Zhang, F Huang… - Journal of …, 2021 - Am Soc Microbiol
Rabies, caused by rabies virus (RABV), remains a serious threat to public health in most
countries worldwide. At present, the administration of rabies vaccines has been the most …

Immune response of inactivated rabies vaccine inoculated via intraperitoneal, intramuscular, subcutaneous and needle-free injection technology-based intradermal …

H Zhao, P Li, L Bian, W Zhang, C Jiang, Y Chen… - International Journal of …, 2023 - mdpi.com
Inoculation routes may significantly affect vaccine performance due to the local
microenvironment, antigen localization and presentation, and, therefore, final immune …

Lab-attenuated rabies virus facilitates opening of the blood-brain barrier by inducing matrix metallopeptidase 8

A Fang, Y Yuan, F Huang, C Wang, D Tian… - Journal of …, 2022 - Am Soc Microbiol
Infection with laboratory-attenuated rabies virus (RABV), but not wild-type (wt) RABV, can
enhance the permeability of the blood-brain barrier (BBB), which is considered a key …