Objectives The recent viral pandemic poses a unique challenge for healthcare providers.
Despite the remarkable progress, the number of novel antiviral agents in the pipeline is …

Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

An efficient and eco-friendly protocol for the construction of naphtho [2, 1-d] thiazol-2-amines
through visible-light photoredoxcatalyzed C (sp 2)-H/SH cross-dehydrogenative coupling …

Background: Thiazole is a good nucleus owing to its various pharmaceutical applications.
Thiazole containing compounds (thiazoles) have shown various biological activities like …

Drug resistance is prevalent across many diseases, rendering therapies ineffective with
severe financial and health consequences. Rather than accepting resistance after the fact …

The review is devoted to modern trends in the chemistry of 2-amino and 2-mercapto
substituted benzothiazoles covering the literature since 2015. The reviewed heterocycles …

Human immunodeficiency virus (HIV) especially HIV-1 infection and its progression to
acquired immune deficiency syndrome (AIDS) remains a significant global health challenge …

We report our recent development of a conceptually new generation of exceptionally potent
non-peptidic HIV-1 protease inhibitors that displayed excellent pharmacological and drug …

Boronic acids have been typecast as moieties for covalent complexation and are employed
only rarely as agents for non-covalent recognition. By exploiting the profuse ability of a …

Protease inhibitors are the most potent antivirals against HIV-1, but they still lose efficacy
against resistant variants. Improving the resistance profile is key to developing more robust …