How proteins specifically localize to the phospholipid monolayer surface of lipid droplets
(LDs) is being unraveled. We review here the major known pathways of protein targeting to …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Rab proteins are best known for their essential roles in exocytic and endocytic membrane
trafficking, which encompass the constitutive and regulated secretory routes, endocytosis via …

Rab molecular switches are key players in defining membrane identity and regulating
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …

CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …

The mevalonate–isoprenoid–cholesterol biosynthesis pathway plays a key role in human
health and disease. The importance of this pathway is underscored by the discovery that two …

This paper reviews the chemical and functional aspects of the posttranslational
modifications of proteins, which are achieved by the addition of various groups to the side …

Warburg Micro syndrome and Martsolf syndrome are heterogenous autosomal-recessive
developmental disorders characterized by brain, eye, and endocrine abnormalities …

Rho GTPases are key molecular switches controlling the transduction of external signals to
cytoplasmic and nuclear effectors. In the last few years, the development of genetic and …

The lipid droplet (LD) is an organelle with vital functions found in nearly all organisms. LD
proteomic research has provided fundamentally important insights into this organelle's …