Natural compounds have significant anticancer pharmacological activities, but often suffer
from low bioavailability and selectivity that limit therapeutic use. The present work critically …

Nowadays, polyphenols as bioactive compounds are being used in producing anti-cancer
drugs. Low stability against harsh environmental conditions, untargeted release, low …

Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class
of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to …

The focus on nanotechnology for improved bioavailability and drug delivery is of increasing
importance for control of different human diseases. Therefore, numerous nanoformulations …

Advances in the development of anti-tumour drugs and related technologies have resulted
in a significant increase in the number of cancer survivors. However, the incidence of …

Cancer is a worldwide disease that causes millions of cases of mortality and morbidity. The
major problem associated with the cancer is its resistance to conventional therapy and a …

Aims MicroRNAs (miRNAs) are non-coding RNAs that control post-transcriptional gene
expression. Recently, miRNAs were confirmed to be promising biomarkers for different …

The long-term success of standard anticancer monotherapeutic strategies has been
hampered by intolerable side effects, resistance to treatment and cancer relapse. These …

Aims Adult T-cell leukemia (ATL) is a mature T-cell neoplasm associated with human T-cell
lymphotropic virus (HTLV-1) infection. Major limitations in Doxorubicin (Dox) chemotherapy …

Hepatocellular carcinoma (HCC) is characterized by its high vascularity and metastasis.
Thymoquinone (TQ), the main bio-active constituent of Nigella sativa, has shown anticancer …