Mitochondria and mood: mitochondrial dysfunction as a key player in the manifestation of depression
Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …
depression. Although depression has historically been linked to alterations in …
The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment
A Giménez-Palomo, S Dodd, G Anmella… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …
energy production. Several studies have found a relationship between mitochondrial …
Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response
The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …
despite decades of research. In this paper, we make three major claims. First, serotonin …
The neurobiology of depression: an integrated overview from biological theories to clinical evidence
Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …
Antidepressants-and antipsychotics-induced hepatotoxicity
N Todorović Vukotić, J Đorđević, S Pejić… - Archives of …, 2021 - Springer
Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical
presentations that can escalate to acute liver failure. The worldwide increase in the use of …
presentations that can escalate to acute liver failure. The worldwide increase in the use of …
Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders
A Gardner, RG Boles - Progress in Neuro-Psychopharmacology and …, 2011 - Elsevier
For many years, a deficiency of monoamines including serotonin has been the prevailing
hypothesis on depression, yet research has failed to confirm consistent relations between …
hypothesis on depression, yet research has failed to confirm consistent relations between …
Mitochondrial targets of drug toxicity
KB Wallace, AA Starkov - Annual review of pharmacology and …, 2000 - annualreviews.org
Mitochondria have long been recognized as the generators of energy for the cell. Like any
other power source, however, mitochondria are highly vulnerable to inhibition or uncoupling …
other power source, however, mitochondria are highly vulnerable to inhibition or uncoupling …
Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder
GA Behr, JCF Moreira, BN Frey - Oxidative medicine and …, 2012 - Wiley Online Library
Major depressive disorder (MDD) is a common mental disorder associated with a significant
negative impact on quality of life, morbidity/mortality, and cognitive function. Individuals who …
negative impact on quality of life, morbidity/mortality, and cognitive function. Individuals who …
Medication‐induced mitochondrial damage and disease
J Neustadt, SR Pieczenik - Molecular nutrition & food research, 2008 - Wiley Online Library
Since the first mitochondrial dysfunction was described in the 1960s, the medicine has
advanced in its understanding the role mitochondria play in health and disease. Damage to …
advanced in its understanding the role mitochondria play in health and disease. Damage to …
[HTML][HTML] Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis
HA Elgebaly, NM Mosa, M Allach, KF El-Massry… - Biomedicine & …, 2018 - Elsevier
Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative
stress, inflammation and apoptosis - ScienceDirect Skip to main contentSkip to article …
stress, inflammation and apoptosis - ScienceDirect Skip to main contentSkip to article …