Mitochondria and mood: mitochondrial dysfunction as a key player in the manifestation of depression

J Allen, R Romay-Tallon, KJ Brymer… - Frontiers in …, 2018 - frontiersin.org
Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …

The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment

A Giménez-Palomo, S Dodd, G Anmella… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response

PW Andrews, A Bharwani, KR Lee, M Fox… - Neuroscience & …, 2015 - Elsevier
The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …

The neurobiology of depression: an integrated overview from biological theories to clinical evidence

F Ferrari, RF Villa - Molecular neurobiology, 2017 - Springer
Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …

Antidepressants-and antipsychotics-induced hepatotoxicity

N Todorović Vukotić, J Đorđević, S Pejić… - Archives of …, 2021 - Springer
Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical
presentations that can escalate to acute liver failure. The worldwide increase in the use of …

Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders

A Gardner, RG Boles - Progress in Neuro-Psychopharmacology and …, 2011 - Elsevier
For many years, a deficiency of monoamines including serotonin has been the prevailing
hypothesis on depression, yet research has failed to confirm consistent relations between …

Mitochondrial targets of drug toxicity

KB Wallace, AA Starkov - Annual review of pharmacology and …, 2000 - annualreviews.org
Mitochondria have long been recognized as the generators of energy for the cell. Like any
other power source, however, mitochondria are highly vulnerable to inhibition or uncoupling …

Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder

GA Behr, JCF Moreira, BN Frey - Oxidative medicine and …, 2012 - Wiley Online Library
Major depressive disorder (MDD) is a common mental disorder associated with a significant
negative impact on quality of life, morbidity/mortality, and cognitive function. Individuals who …

Medication‐induced mitochondrial damage and disease

J Neustadt, SR Pieczenik - Molecular nutrition & food research, 2008 - Wiley Online Library
Since the first mitochondrial dysfunction was described in the 1960s, the medicine has
advanced in its understanding the role mitochondria play in health and disease. Damage to …

[HTML][HTML] Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis

HA Elgebaly, NM Mosa, M Allach, KF El-Massry… - Biomedicine & …, 2018 - Elsevier
Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative
stress, inflammation and apoptosis - ScienceDirect Skip to main contentSkip to article …