Duchenne muscular dystrophy: Disease mechanism and therapeutic strategies

A Bez Batti Angulski, N Hosny, H Cohen… - Frontiers in …, 2023 - frontiersin.org
Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

[HTML][HTML] A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction

D Jo, G Yoon, OY Kim, J Song - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Sarcopenia characterized by reduced skeletal muscle mass and decreased muscle strength
is increasing in prevalence globally. The pathophysiology of sarcopenia is related to various …

[HTML][HTML] Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress

LJ Delfinis, CA Bellissimo, S Gandhi, SN DiBenedetto… - JCI insight, 2022 - ncbi.nlm.nih.gov
Muscle weakness and wasting are defining features of cancer-induced cachexia.
Mitochondrial stress occurs before atrophy in certain muscles, but the possibility of …

Mitochondrial stress responses in Duchenne muscular dystrophy: metabolic dysfunction or adaptive reprogramming?

CA Bellissimo, MC Garibotti… - American Journal of …, 2022 - journals.physiology.org
Mitochondrial stress may be a secondary contributor to muscle weakness in inherited
muscular dystrophies. Duchenne muscular dystrophy has received the majority of attention …

Cardiovascular disease in Duchenne muscular dystrophy: overview and insight into novel therapeutic targets

TI Schultz, FJ Raucci Jr, FN Salloum - Basic to Translational Science, 2022 - jacc.org
Duchenne muscular dystrophy (DMD) is a devastating disease affecting approximately 1 in
every 3,500 male births worldwide. Multiple mutations in the dystrophin gene have been …

The slow-release adiponectin analog ALY688-SR modifies early-stage disease development in the D2.mdx mouse model of Duchenne muscular dystrophy

CA Bellissimo, S Gandhi… - … of Physiology-Cell …, 2024 - journals.physiology.org
Fibrosis is associated with respiratory and limb muscle atrophy in Duchenne muscular
dystrophy (DMD). Current standard of care partially delays the progression of this myopathy …

Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime

CA Bellissimo, LJ Delfinis… - … of Physiology-Cell …, 2023 - journals.physiology.org
Duchenne muscular dystrophy (DMD) is associated with distinct mitochondrial stress
responses. Here, we aimed to determine whether the prospective mitochondrial-enhancing …

Mitochondrial dysfunction in cardiac arrhythmias

J Deng, Y Jiang, ZB Chen, JW Rhee, Y Deng, ZV Wang - Cells, 2023 - mdpi.com
Electrophysiological and structural disruptions in cardiac arrhythmias are closely related to
mitochondrial dysfunction. Mitochondria are an organelle generating ATP, thereby satisfying …

[HTML][HTML] Cardiomyopathy in Duchenne Muscular Dystrophy and the Potential for Mitochondrial Therapeutics to Improve Treatment Response

S Gandhi, HL Sweeney, CC Hart, R Han, CGR Perry - Cells, 2024 - mdpi.com
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease caused by
mutations to the dystrophin gene, resulting in deficiency of dystrophin protein, loss of …

[HTML][HTML] Muscle weakness and mitochondrial stress occur before severe metastasis in a novel mouse model of ovarian cancer cachexia

LJ Delfinis, LM Ogilvie, S Khajehzadehshoushtar… - Molecular …, 2024 - Elsevier
Objectives A high proportion of women with advanced epithelial ovarian cancer (EOC)
experience weakness and cachexia. This relationship is associated with increased morbidity …