A unifying concept that combines the basic features governing self-organization of proteins
into complex three-dimensional structures in vitro and in vivo is still lacking. Recent …

Combinatorial approaches in biology require appropriate screening methods for very large
libraries. The library size, however, is almost always limited by the initial transformation …

The problem of how the linear amino acid sequence of a polypeptide folds to assume its
unique tertiary structure is one of the most basic and challenging conundrums of …

The mammalian GSPT, which consists of amino-terminal (N) and carboxyl-terminal (C)
domains, functions as the eukaryotic releasing factor 3 (eRF3) by interacting with eRF1 in …

Over the past two decades, library-based display technologies have been staggeringly
optimized since their appearance in order to mimic the process of natural molecular …

This book is based on an advanced course of lectures on ribosome structure and protein
biosynthesis that I offer at the Moscow State University. These lectures have been part of a …

Prokaryotic and eukaryotic in vitro translation systems have recently become the focus of
increasing interest for tackling fundamental problems in biochemistry. Cell-free systems can …

Recent genetic data suggest that proteins homologous to a plant RNA-dependent RNA
polymerase (RdRP) play a central role in posttranscriptional gene silencing (PTGS) in many …

Although tertiary folding of whole protein domains is prohibited by the cramped dimensions
of the ribosomal tunnel, dynamic tertiary interactions may permit folding of small elementary …

In living systems, polypeptide chains are synthesised on ribosomes, molecular machines
composed of over 50 protein and nucleic acid molecules. As nascent chains emerge from …