Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120
Summary While HIV-1-mediated CD4 downregulation protects infected cells from antibody-
dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander …
dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander …
Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein
T Tong, A D'Addabbo, J Xu, H Chawla… - PLoS …, 2023 - journals.plos.org
Recent HIV-1 vaccine development has centered on “near native” soluble envelope
glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and …
glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and …
Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles
During virus entry, the pretriggered human immunodeficiency virus (HIV-1) envelope
glycoprotein (Env) trimer initially transits into a default intermediate state (DIS) that remains …
glycoprotein (Env) trimer initially transits into a default intermediate state (DIS) that remains …
Characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein conformational states on infectious virus particles
ABSTRACT Human immunodeficiency virus (HIV-1) entry into cells involves triggering of the
viral envelope glycoprotein (Env) trimer ([gp120/gp41] 3) by the primary receptor, CD4, and …
viral envelope glycoprotein (Env) trimer ([gp120/gp41] 3) by the primary receptor, CD4, and …
Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein …
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer mediates
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir
The HIV-1 entry inhibitor temsavir prevents the viral receptor CD4 (cluster of differentiation 4)
from interacting with the envelope glycoprotein (Env) and blocks its conformational changes …
from interacting with the envelope glycoprotein (Env) and blocks its conformational changes …
Global increases in human immunodeficiency virus neutralization sensitivity due to alterations in the membrane-proximal external region of the envelope glycoprotein …
Binding to the receptor, CD4, drives the pretriggered,“closed”(State-1) conformation of the
human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer ([gp120/gp41] 3) …
human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer ([gp120/gp41] 3) …
Conformations of human immunodeficiency virus envelope glycoproteins in detergents and styrene-maleic acid lipid particles
The mature human immunodeficiency virus (HIV) envelope glycoprotein (Env) trimer, which
consists of noncovalently associated gp120 exterior and gp41 transmembrane subunits …
consists of noncovalently associated gp120 exterior and gp41 transmembrane subunits …
Conformations of membrane human immunodeficiency virus (HIV-1) envelope glycoproteins solubilized in Amphipol A18 lipid-nanodiscs
Upon binding to the host cell receptor, CD4, the pretriggered (State-1) conformation of the
human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer undergoes …
human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer undergoes …
Inducible cell lines producing replication-defective human immunodeficiency virus particles containing envelope glycoproteins stabilized in a pretriggered …
H Ding, HT Nguyen, W Li, A Deshpande… - Journal of …, 2024 - journals.asm.org
During the process by which human immunodeficiency virus (HIV-1) enters cells, the
envelope glycoprotein (Env) trimer on the virion surface engages host cell receptors …
envelope glycoprotein (Env) trimer on the virion surface engages host cell receptors …