Covariate adjustment in randomized controlled trials: General concepts and practical considerations
There has been a growing interest in covariate adjustment in the analysis of randomized
controlled trials in past years. For instance, the US Food and Drug Administration recently …
controlled trials in past years. For instance, the US Food and Drug Administration recently …
A Unified Framework for Covariate Adjustment Under Stratified Randomisation
Randomisation, as a key technique in clinical trials, can eliminate sources of bias and
produce comparable treatment groups. In randomised experiments, the treatment effect is a …
produce comparable treatment groups. In randomised experiments, the treatment effect is a …
Automated, efficient and model-free inference for randomized clinical trials via data-driven covariate adjustment
In May 2023, the US Food and Drug Administration (FDA) released guidance for industry on"
Adjustment for Covariates in Randomized Clinical Trials for Drugs and Biological Products" …
Adjustment for Covariates in Randomized Clinical Trials for Drugs and Biological Products" …
[HTML][HTML] When does adjusting covariate under randomization help? A comparative study on current practices
Y Gao, Y Liu, R Matsouaka - BMC Medical Research Methodology, 2024 - Springer
Purpose We aim to thoroughly compare past and current methods that leverage baseline
covariate information to estimate the average treatment effect (ATE) using data from of …
covariate information to estimate the average treatment effect (ATE) using data from of …
Incorporating external data for analyzing randomized clinical trials: A transfer learning approach
Randomized clinical trials are the gold standard for analyzing treatment effects, but high
costs and ethical concerns can limit recruitment, potentially leading to invalid inferences …
costs and ethical concerns can limit recruitment, potentially leading to invalid inferences …
Covariate adjustment and estimation of difference in proportions in randomized clinical trials
J Liu, D Xi - Pharmaceutical Statistics, 2024 - Wiley Online Library
Difference in proportions is frequently used to measure treatment effect for binary outcomes
in randomized clinical trials. The estimation of difference in proportions can be assisted by …
in randomized clinical trials. The estimation of difference in proportions can be assisted by …