Malaria is among the most devastating and widespread tropical parasitic diseases in which
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …

Background Malaria is an extremely devastating disease that continues to affect millions of
people each year. A distinctive attribute of malaria infected red blood cells is the presence of …

Experimenta naturae, like the glucose-6-phosphate dehydrogenase deficiency, indicate that
malaria parasites are highly susceptible to alterations in the redox equilibrium. This offers a …

By using cell fractionation and measurement of Fe (III) heme-pyridine, the antimalarial
chloroquine (CQ) has been shown to cause a dose-dependent decrease in hemozoin and …

Conspectus Over the last century, malaria deaths have decreased by more than 85%.
Nonetheless, there were 405 000 deaths in 2018, mostly resulting from Plasmodium …

The malaria parasite Plasmodium falciparum is highly adapted to cope with the oxidative
stress to which it is exposed during the erythrocytic stages of its life cycle. This includes the …

Malaria caused by Plasmodium affects millions people worldwide. Plasmodium consumes
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …

Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Artemisinins form the most important class of antimalarial currently available, particularly
because they are effective against parasites resistant to almost all the other classes. Their …

To ensure their survival in the human bloodstream, malaria parasites degrade up to 80% of
the host erythrocyte hemoglobin in an acidified digestive vacuole. Here, we combine …