Biological underpinnings for lifelong learning machines

D Kudithipudi, M Aguilar-Simon, J Babb… - Nature Machine …, 2022 - nature.com
Biological organisms learn from interactions with their environment throughout their lifetime.
For artificial systems to successfully act and adapt in the real world, it is desirable to similarly …

[HTML][HTML] Future medicine: from molecular pathways to the collective intelligence of the body

E Lagasse, M Levin - Trends in Molecular Medicine, 2023 - cell.com
The remarkable anatomical homeostasis exhibited by complex living organisms suggests
that they are inherently reprogrammable information-processing systems that offer …

Technological approach to mind everywhere: an experimentally-grounded framework for understanding diverse bodies and minds

M Levin - Frontiers in systems neuroscience, 2022 - frontiersin.org
Synthetic biology and bioengineering provide the opportunity to create novel embodied
cognitive systems (otherwise known as minds) in a very wide variety of chimeric …

A novel injectable piezoelectric hydrogel for periodontal disease treatment

L Roldan, C Montoya, V Solanki, KQ Cai… - … Applied Materials & …, 2023 - ACS Publications
Periodontal disease is a multifactorial, bacterially induced inflammatory condition
characterized by the progressive destruction of periodontal tissues. The successful …

Synthetic morphology with agential materials

J Davies, M Levin - Nature Reviews Bioengineering, 2023 - nature.com
Bioengineering can address many important needs, from transformative biomedicine to
environmental remediation. In addition to practical applications, the construction of new …

Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind

M Levin - Animal Cognition, 2023 - Springer
Each of us made the remarkable journey from mere matter to mind: starting life as a
quiescent oocyte (“just chemistry and physics”), and slowly, gradually, becoming an adult …

Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut

A Petsakou, Y Liu, Y Liu, A Comjean, Y Hu, N Perrimon - Nature, 2023 - nature.com
A fundamental and unresolved question in regenerative biology is how tissues return to
homeostasis after injury. Answering this question is essential for understanding the …

[HTML][HTML] PLLA scaffolds with controlled surface potential and piezoelectricity for enhancing cell adhesion in tissue engineering

M Polak, K Berniak, PK Szewczyk… - Applied Surface …, 2023 - Elsevier
The effect of the surface potential of biomaterials on cell attachment and development in
regenerative medicine is still an unexplored area driving many regeneration processes …

Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice

J Zhu, R Patel, A Trofka, BD Harfe, S Mackem - Developmental cell, 2022 - cell.com
Limb patterning by Sonic hedgehog (Shh), via either graded spatial or temporal signal
integration, is a paradigm for" morphogen" function, yet how Shh instructs distinct digit …

There's plenty of room right here: Biological systems as evolved, overloaded, multi-scale machines

J Bongard, M Levin - Biomimetics, 2023 - mdpi.com
The applicability of computational models to the biological world is an active topic of debate.
We argue that a useful path forward results from abandoning hard boundaries between …