Testicular cancer is rare overall but comprises the most common solid malignancy
diagnosed in young men aged∼ 20–40 years. Most testicular neoplasms generally fall into …

The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies
strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In …

There is cumulative evidence that iprodione (IPR) fungicide and chlorpyrifos (CPF)
insecticide are endocrine disruptors that can evoke reproductive toxicity. Yet, the underlying …

A comprehensive immunohistochemical ontogeny of the developing human fetal testis has
remained incomplete in the literature to date. We collected human fetal testes from 8 to 21 …

Nuclear receptor subfamily 5 group A member 1 (NR5A1) encodes steroidogenic factor 1
(SF1), a key regulatory factor that determines gonadal development and coordinates …

In brief The nuclear receptor steroidogenic factor 1 (SF-1) is essential for mature mouse
gonad steroidogenic gene expression, for Leydig and Sertoli cell function, and depletion of …

In mammals, gonadal somatic cell lineage differentiation determines the development of the
bipotential gonad into either the ovary or testis. Sertoli cells, the only somatic cells in the …

Abstract Steroidogenic factor 1 (NR5A1) is essential for gonadal development. To study the
importance of NR5A1 during early gonadal sex differentiation, we generated Sox9-Cre …

Hybrid male sterility (HMS) is a reproductive isolation mechanism limiting the formation of
fertile offspring through interspecific fertilization. Cattleyak is the interspecific hybrid …

Gonad development includes sex determination and divergent maturation of the testes and
ovaries. Recent advances in measuring gene expression in single cells are providing new …