Machine intelligence in peptide therapeutics: A next‐generation tool for rapid disease screening
S Basith, B Manavalan, T Hwan Shin… - Medicinal research …, 2020 - Wiley Online Library
Discovery and development of biopeptides are time‐consuming, laborious, and dependent
on various factors. Data‐driven computational methods, especially machine learning (ML) …
on various factors. Data‐driven computational methods, especially machine learning (ML) …
Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers
D Rong, G Sun, F Wu, Y Cheng, G Sun, W Jiang… - … Therapy-Nucleic Acids, 2021 - cell.com
As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA
modification processes have been reported, and they are widely present in every organism …
modification processes have been reported, and they are widely present in every organism …
An interpretable prediction model for identifying N7-methylguanosine sites based on XGBoost and SHAP
Recent studies have increasingly shown that the chemical modification of mRNA plays an
important role in the regulation of gene expression. N 7-methylguanosine (m7G) is a type of …
important role in the regulation of gene expression. N 7-methylguanosine (m7G) is a type of …
HLPpred-Fuse: improved and robust prediction of hemolytic peptide and its activity by fusing multiple feature representation
Motivation Therapeutic peptides failing at clinical trials could be attributed to their toxicity
profiles like hemolytic activity, which hamper further progress of peptides as drug …
profiles like hemolytic activity, which hamper further progress of peptides as drug …
Deep-Kcr: accurate detection of lysine crotonylation sites using deep learning method
As a newly discovered protein posttranslational modification, histone lysine crotonylation
(Kcr) involved in cellular regulation and human diseases. Various proteomics technologies …
(Kcr) involved in cellular regulation and human diseases. Various proteomics technologies …
Attention-based multi-label neural networks for integrated prediction and interpretation of twelve widely occurring RNA modifications
Recent studies suggest that epi-transcriptome regulation via post-transcriptional RNA
modifications is vital for all RNA types. Precise identification of RNA modification sites is …
modifications is vital for all RNA types. Precise identification of RNA modification sites is …
Design powerful predictor for mRNA subcellular location prediction in Homo sapiens
Messenger RNAs (mRNAs) shoulder special responsibilities that transmit genetic code from
DNA to discrete locations in the cytoplasm. The locating process of mRNA might provide …
DNA to discrete locations in the cytoplasm. The locating process of mRNA might provide …
RMDisease: a database of genetic variants that affect RNA modifications, with implications for epitranscriptome pathogenesis
Deciphering the biological impacts of millions of single nucleotide variants remains a major
challenge. Recent studies suggest that RNA modifications play versatile roles in essential …
challenge. Recent studies suggest that RNA modifications play versatile roles in essential …
m7GHub: deciphering the location, regulation and pathogenesis of internal mRNA N7-methylguanosine (m7G) sites in human
Motivation Recent progress in N7-methylguanosine (m7G) RNA methylation studies has
focused on its internal (rather than capped) presence within mRNAs. Tens of thousands of …
focused on its internal (rather than capped) presence within mRNAs. Tens of thousands of …
Internal m7G methylation: a novel epitranscriptomic contributor in brain development and diseases
In recent years, N7-methylguanosine (m7G) methylation, originally considered as
messenger RNA (mRNA) 5′ caps modifications, has been identified at defined internal …
messenger RNA (mRNA) 5′ caps modifications, has been identified at defined internal …