[HTML][HTML] Evolving concepts in NAD+ metabolism
CCS Chini, JD Zeidler, S Kashyap, G Warner, EN Chini - Cell metabolism, 2021 - cell.com
Summary NAD (H) and NADP (H) have traditionally been viewed as co-factors (or co-
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children
Most studies of adaptive immunity to SARS-CoV-2 infection focus on peripheral blood, which
may not fully reflect immune responses at the site of infection. Using samples from 110 …
may not fully reflect immune responses at the site of infection. Using samples from 110 …
Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy
S Kaczanowska, T Murty, A Alimadadi, CF Contreras… - Cancer Cell, 2024 - cell.com
Chimeric antigen receptor T cells (CAR-Ts) have remarkable efficacy in liquid tumors, but
limited responses in solid tumors. We conducted a Phase I trial (NCT02107963) of GD2 …
limited responses in solid tumors. We conducted a Phase I trial (NCT02107963) of GD2 …
Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19
M Cutolo, V Smith, S Paolino, E Gotelli - Nature Reviews Rheumatology, 2023 - nature.com
Evidence supporting the extra-skeletal role of vitamin D in modulating immune responses is
centred on the effects of its final metabolite, 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3, also …
centred on the effects of its final metabolite, 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3, also …
The role of CD38 in inflammation-induced depression-like behavior and the antidepressant effect of (R)-ketamine
X Zhang, T He, Z Wu, Y Wang, H Liu, B Zhang… - Brain, Behavior, and …, 2024 - Elsevier
CD38 is involved in immune responses, cell proliferation, and has been identified in the
brain, where it is implicated in inflammation processes and psychiatric disorders. We …
brain, where it is implicated in inflammation processes and psychiatric disorders. We …
B cell depletion therapies in autoimmune diseases: Monoclonal antibodies or chimeric antigen receptor-based therapy?
Immune system detects foreign pathogens, distinguishes them from self-antigens and
responds to defend human body. When this self-tolerance is disrupted, the overactive …
responds to defend human body. When this self-tolerance is disrupted, the overactive …
A link between mitochondrial dysfunction and the immune microenvironment of salivary glands in primary Sjogren's syndrome
N Li, Y Li, J Hu, Y Wu, J Yang, H Fan, L Li… - Frontiers in …, 2022 - frontiersin.org
Background Primary Sjogren's syndrome (pSS) is a slowly progressive, inflammatory
autoimmune disease characterized by lymphocytic infiltration into salivary and lacrimal …
autoimmune disease characterized by lymphocytic infiltration into salivary and lacrimal …
Development of exhausted memory monocytes and underlying mechanisms
Pathogenic inflammation and immuno-suppression are cardinal features of exhausted
monocytes increasingly recognized in septic patients and murine models of sepsis …
monocytes increasingly recognized in septic patients and murine models of sepsis …
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
JD Zeidler, KA Hogan, G Agorrody… - … of Physiology-Cell …, 2022 - journals.physiology.org
Nicotinamide adenine dinucleotide (NAD) acts as a cofactor in several oxidation-reduction
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …