Glucuronide conjugates represent one of the major types of naturally occurring phase 2
metabolites of xenobiotics and endobiotics. The process underlying their formation …

This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …

Androgens and estrogens play major roles in cell differentiation, cell growth, and peptide
secretion in steroid target tissues. In addition to the binding of these hormones to their …

Metabolic disposition of drugs and other xenobiotics includes glucuronidation reactions that
are catalyzed by the uridine diphosphate glucuronosyltransferases (UGTs). The most …

During the inflammatory response, intrahepatic cholestasis and decreased drug metabolism
are frequently observed. At the hepatic level, the orphan nuclear constitutive androstane …

The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant
of our response to those chemicals that are primarily eliminated by conjugation with …

Bilirubin, the oxidative product of heme in mammals, is excreted into the bile after its
esterification with glucuronic acid to polar mono-and diconjugated derivatives. The …

The domestic cat has a significantly lower capacity to glucuronidate planar phenolic
xenobiotics compared with most other mammalian species. The aim of this study was to …

The interactions between UDP-glucuronosyltransferase (UGT) isozymes, UGT1s and
UGT2B1, in rat hepatic microsomes were investigated using an immunopurification …

We have previously demonstrated that in mice, the decrease in serum thyroxine (T4) level by
polychlorinated biphenyls (PCBs) occurs without an increase in the UDP …