Regulation of white adipogenesis and its relation to ectopic fat accumulation and cardiovascular risk

B Gustafson, U Smith - Atherosclerosis, 2015 - Elsevier
The subcutaneous adipose tissue (SAT) is the largest and least harmful adipose depot to
store excess lipids. However, SAT has a limited ability to expand and recruit new cells …

Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

S Udayappan, L Manneras-Holm… - NPJ biofilms and …, 2016 - nature.com
An altered intestinal microbiota composition is associated with insulin resistance and type 2
diabetes mellitus. We previously identified increased intestinal levels of Eubacterium hallii …

Is insulin resistance tissue-dependent and substrate-specific? The role of white adipose tissue and skeletal muscle

D Calderón-DuPont, I Torre-Villalvazo… - Biochimie, 2023 - Elsevier
Insulin resistance (IR) refers to a reduction in the ability of insulin to exert its metabolic
effects in organs such as adipose tissue (AT) and skeletal muscle (SM), leading to chronic …

Study on community structure and metabolic mechanism of dominant polyphosphate-accumulating organisms (PAOs) and glycogen-accumulating organisms (GAOs) …

M Ni, Y Chen, Y Pan, Y Huang, D Li, L Li… - Science of The Total …, 2022 - Elsevier
Biofilm sequencing batch reactor (BSBR) can achieve efficient phosphate (P) removal and
enrichment, but its process performance and metabolic mechanisms for P removal and …

Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH

M Amrutkar, E Cansby, E Nuñez‐Durán… - The FASEB …, 2015 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease, and 10%
to 20% of NAFLD patients progress to nonalcoholic steatohepatitis (NASH). The molecular …

[HTML][HTML] Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiring

Y Xia, E Andersson, SK Anand, E Cansby… - Hepatology …, 2023 - journals.lww.com
Background: NAFLD has become the leading cause of chronic liver disease worldwide
afflicting about one quarter of the adult population. NASH is a severe subtype of NAFLD …

[HTML][HTML] Targeted delivery of Stk25 antisense oligonucleotides to hepatocytes protects mice against nonalcoholic fatty liver disease

E Cansby, E Nuñez-Durán, E Magnusson… - Cellular and Molecular …, 2019 - Elsevier
Background & Aims Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic
steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide …

STE20‐type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver …

M Caputo, Y Xia, SK Anand, E Cansby… - The FASEB …, 2023 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most fatal and fastest growing malignancies.
Recently, nonalcoholic steatohepatitis (NASH), characterized by liver steatosis …

Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans

M Amrutkar, M Kern, E Nuñez-Durán, M Ståhlman… - Diabetologia, 2016 - Springer
Aims/hypothesis Type 2 diabetes is closely associated with pathological lipid accumulation
in the liver, which is suggested to actively contribute to the development of insulin …

Genetic disruption of protein kinase STK25 ameliorates metabolic defects in a diet-induced type 2 diabetes model

M Amrutkar, E Cansby, U Chursa, E Nuñez-Durán… - Diabetes, 2015 - Am Diabetes Assoc
Understanding the molecular networks controlling ectopic lipid deposition, glucose
tolerance, and insulin sensitivity is essential to identifying new pharmacological approaches …