ABSTRACT Introduction: Fluzone® High-Dose (IIV3-HD) is a trivalent, inactivated, split-virus
influenza vaccine indicated for use in older adults (≥ 65 years of age). It contains 60 µg …

Background Immune responses to influenza vaccines decline with age, reducing clinical
effectiveness. We compared the effect of the more immunogenic high-dose trivalent …

The need for a systematic approach to research on vaccine effectiveness (VE) is increasing
with growing numbers of vaccines and complexity of immunization programs. The diverse …

Background Nursing home residents are frail, have multiple medical comorbidities, and are
at high risk for delirium. Most of the existing evidence base on delirium is derived from …

As a method of research, pragmatic trials are recommended so as to generate results that
are applicable to real-world care. This intent is especially important for the millions of older …

When planning a cluster randomized trial, evaluators often have access to an enumerated
cohort representing the target population of clusters. Practicalities of conducting the trial …

Longitudinal studies are often applied in biomedical research and clinical trials to evaluate
the treatment effect. The association pattern within the subject must be considered in both …

Objectives Influenza is a leading cause of avoidable admissions for nursing home (NH)
residents. We previously evaluated the effectiveness of a high-dose trivalent influenza …

There is growing interest in conducting cluster randomized trials (CRTs). For simplicity in
sample size calculation, the cluster sizes are assumed to be identical across all clusters …

Cluster randomized trials (CRT) of non‐pharmacological interventions are an important
means of improving the quality of care and quality of life of people living with dementia …