Poor water solubility of many drugs has emerged as one of the major challenges in the
pharmaceutical world. Polymer-based amorphous solid dispersions have been considered …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Spray drying is an efficient technology for solid dispersion manufacturing since it allows
extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to …

The use of amorphous solid dispersions is an interesting strategy to increase the
bioavailability of poorly soluble drugs by improving their rate and extent of dissolution. Lack …

Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …

Amorphous solid dispersion (ASD) can accelerate a project by improving dissolution rate
and solubility, offering dose escalation flexibility and excipient acceptance for toxicology …

Amorphous drug–polymer solid dispersions have the potential to enhance the dissolution
performance and thus bioavailability of BCS class II drug compounds. The principle …

Aqueous solubility of an active pharmaceutical ingredient is an important consideration to
ensure successful drug development. Mesoporous materials have been investigated as an …

Introduction: In recent years, the number of active pharmaceutical ingredients with high
therapeutic impact, but very low water solubility, has increased significantly. Thus, a great …

The preparation of amorphous solid dispersion (ASD) formulations is a promising strategy to
improve the bioavailability of an active pharmaceutical ingredient (API). By dissolving the …