Abstract Nrf2: INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress. Nrf2 is
a nuclear factor that controls the expression and coordinated induction of a battery of genes …

Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
and its potential as a serious environmental health threat is beginning to be recognized …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

The gastrointestinal tract is considered as one of the main target organs affected by heat
stress. Phytogenic feed additives containing phenolics and flavonoids can improve the …

The nuclear factor E2-related factor 2 (Nrf2) plays an important role in cellular protection
against cancer, renal, pulmonary, cardiovascular and neurodegenerative diseases where …

Mitochondria are essential organelles for cellular integrity and functionality maintenance
and their imparement is implicated in the development of a wide range of diseases …

Cells in aerobic condition are constantly exposed to reactive oxygen species (ROS), which
may induce damage to biomolecules, including proteins, nucleic acids and lipids. In normal …

Purpose: Oxidative stress on retinal pigment epithelial (RPE) cells is thought to play a crucial
role in the development and progression of age-related macular degeneration. Astaxanthin …

Significance: Epidemiological studies indicate that metabolic disorders are associated with
an increased risk for Alzheimer's disease (AD). Metabolic remodeling occurs in the central …

Diabetic retinopathy (DR) is a major microvascular complication that can lead to severe
visual impairment in patients with diabetes. The elevated oxidative stress and increased …