Aging is accompanied by the deterioration of hearing that complicates our understanding of
speech, especially in noisy environments. This deficit is partially caused by the loss of hair …

Background Primary brain tumors are among the ten most common causes of cancer-related
death. There is no screening test for them, but timely diagnosis and treatment improve the …

Mutations of the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are commonly
found in primary brain cancers. We previously reported that a novel enzymatic activity of …

We show here that hyperpolarized [1‐13C] pyruvate can be used to detect treatment
response in a glioma tumor model; a tumor type where detection of response with 18fluoro …

Brain tumors and brain metastases induce changes in brain tissue remodeling that lead to
immunosuppression and trigger an inflammatory response within the tumor …

Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Diffuse brainstem glioma has a poor prognosis, and there are few long-term survivors. We
looked for clinical, conventional magnetic resonance (MR), and MR spectroscopic (MRS) …

Glioblastoma is a highly malignant brain tumor that relentlessly defies therapy. Efforts over
the past decade have begun to tease out the biochemical details that lead to its aggressive …

Background The objective of this study was to examine the predictive value of parameters of
3D 1H magnetic resonance spectroscopic imaging (MRSI) prior to treatment with radiation …

The creatine/creatine kinase (CK) system plays a key role in cellular energy buffering and
transport. In vertebrates, CK has four isoforms expressed in a tissue-specific manner. In the …