[HTML][HTML] Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

A Ahmad, RK Mishra, A Vyawahare, A Kumar… - Saudi Pharmaceutical …, 2019 - Elsevier
Cancer remains the topmost disorder of the mankind and number of cases is unceasingly
growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the …

Thymoquinone, as a novel therapeutic candidate of cancers

B Almajali, HAN Al-Jamal, WRW Taib, I Ismail… - Pharmaceuticals, 2021 - mdpi.com
To date, natural products are widely used as pharmaceutical agents for many human
diseases and cancers. One of the most popular natural products that have been studied for …

[HTML][HTML] The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies

M Butnariu, C Quispe, J Herrera-Bravo, P Helon… - Biomedicine & …, 2022 - Elsevier
Thymoquinone (TQ) is a secondary metabolite found in abundance in very few plant species
including Nigella sativa L., Monarda fistulosa L., Thymus vulgaris L. and Satureja montana …

A patent review on the current developments of benzoxazoles in drug discovery

XK Wong, KY Yeong - ChemMedChem, 2021 - Wiley Online Library
The benzoxazole moiety is widely found in various natural compounds, which are often
found to be biologically active. Due to its versatile biological properties, benzoxazole has …

Anticancer activity of benzoxazole derivative (2015 onwards): a review

T Ghoshal, TM Patel - Future Journal of Pharmaceutical Sciences, 2020 - Springer
Background According to the report published recently by the World Health Organization,
the number of cancer cases in the world will increase to 22 million by 2030. So the …

Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents

N Bayrak, H Yıldırım, M Yıldız, MO Radwan… - Bioorganic …, 2019 - Elsevier
In this paper, based on Plastoquinone (PQ) analogs possessing substituted aniline
containing alkoxy group (s), new 2, 3-dimethyl-5-amino-1, 4-benzoquinones (PQ1-15) were …

In vitro and in silico study of analogs of plant product plastoquinone to be effective in colorectal cancer treatment

H Ciftci, B Sever, F Ocak, N Bayrak, M Yıldız, H Yıldırım… - Molecules, 2022 - mdpi.com
Plants have paved the way for the attainment of molecules with a wide-range of biological
activities. However, plant products occasionally show low biological activities and/or poor …

Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer's disease

FZ Khan, MS Mostaid, MNH Apu - Heliyon, 2022 - cell.com
Alzheimer's disease (AD) is a neurodegenerative disease with rapid progression. Black
cumin (Nigella sativa) is a nutraceutical that has been investigated as a prophylactic and …

Chlorinated plastoquinone analogs that inhibit Staphylococcus epidermidis and Candida albicans growth

EM Kara, N Bayrak, H Yıldırım, M Yıldız, BO Celik… - Folia Microbiologica, 2020 - Springer
Infectious diseases are the significant global health problem because of drug resistance to
most classes of antimicrobials. Interest is growing in the development of new antimicrobials …

Discovery of a new family of heterocyclic amine linked plastoquinone analogs for antimicrobial evaluation

AF Tuyun, M Yıldız, N Bayrak, H Yıldırım… - Drug Development …, 2019 - Wiley Online Library
A series of aminobenzoquinones, denoted as PQ analogs (PQ1‐13), were synthesized by
employing a green methodology approach using water as solvent developed by Tandon et …