To enable survival in adverse conditions, cancer cells undergo global metabolic
adaptations. The amino acid cysteine actively contributes to cancer metabolic remodelling …

Metabolic reprogramming is one of the hallmarks of tumors. Alterations of cellular
metabolism not only contribute to tumor development, but also mediate the resistance of …

Ferroptosis is a kind of iron-dependent regulatory necrosis characterized by the fatal
accumulation of iron-dependent lipid peroxides in the plasma membrane and the final …

Glutathione (GSH) is the predominant low-molecular-weight antioxidant with a ubiquitous
distribution inside the cell. The steady-state level of cellular GSH is dependent on the …

Clinical efficacy of oxaliplatin is frequently limited by severe adverse effects and therapy
resistance. Acquired insensitivity to oxaliplatin is, at least in part, associated with elevated …

Ovarian cancer is a silent cancer which rate survival mainly relays in early stage detection.
The discovery of reliable ovarian cancer biomarkers plays a crucial role in the disease …

Cancer cells are characterized by higher levels of reactive oxygen species (ROS) compared
to normal cells as a result of an imbalance between oxidants and antioxidants. However …

Glutathione (GSH) has several roles in a cell, such as a reactive oxygen species (ROS)
scavenger, an intervenient in xenobiotics metabolism and a reservoir of cysteine. All of these …

Cancer is a death cause in economically developed countries that results growing also in
developing countries. Improved outcome through targeted interventions faces the scarce …

Resistance to platinum-based chemotherapy is a major clinical challenge in ovarian cancer,
contributing to the high mortality-to-incidence ratio. Management of the platinum-resistant …