Inside the β cell: molecular stress response pathways in diabetes pathogenesis

A Kulkarni, C Muralidharan, SC May, SA Tersey… - …, 2023 - academic.oup.com
The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to
their major molecular insults (loss of immune tolerance and onset of tissue insulin …

Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation

E Ermis, T Nargis, K Webster, SA Tersey… - Journal of Biological …, 2024 - ASBMB
Chronic inflammation is the underlying cause of many diseases, including type 1 diabetes,
obesity, and non-alcoholic fatty liver disease. Macrophages are continuously recruited to …

Inflammation in Development and Aging: Insights from the Zebrafish Model

M Mastrogiovanni, FJ Martínez-Navarro… - International Journal of …, 2024 - mdpi.com
Zebrafish are an emergent animal model to study human diseases due to their significant
genetic similarity to humans, swift development, and genetic manipulability. Their utility …

Anti-inflammatory reprogramming of microglia cells by metabolic modulators to counteract neurodegeneration; a new role for Ranolazine

I Piano, A Votta, P Colucci, F Corsi, S Vitolo, C Cerri… - Scientific Reports, 2023 - nature.com
Microglia chronic activation is a hallmark of several neurodegenerative diseases, including
the retinal ones, possibly contributing to their etiopathogenesis. However, some microglia …

The use of the Crude Extract of Immuno-activated C. Elegans as a Treatment for Inflammation

M Owusu, L Joykutty - Journal of Student Research, 2023 - jsr.org
Helminth Therapy is the practice of infecting oneself with parasites to cure ailments. The
hypothesis was formed in the 20th century and experimentation began around 10 years ago …