Diabetes-induced chronic heart failure is due to defects in calcium transporting and regulatory contractile proteins: cellular and molecular evidence
S Rupee, K Rupee, RB Singh, C Hanoman… - Heart Failure …, 2023 - Springer
Heart failure (HF) is a major deteriorating disease of the myocardium due to weak
myocardial muscles. As such, the heart is unable to pump blood efficiently around the body …
myocardial muscles. As such, the heart is unable to pump blood efficiently around the body …
[HTML][HTML] The dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology
M Cairns, D Joseph, MF Essop - Frontiers in endocrinology, 2022 - frontiersin.org
The heart is a highly metabolic organ with extensive energy demands and hence relies on
numerous fuel substrates including fatty acids and glucose. However, oxidative stress is a …
numerous fuel substrates including fatty acids and glucose. However, oxidative stress is a …
Treadmill running increases the calcium sensitivity of myofilaments in diabetic rats
AC Greenman, GM Diffee, AS Power… - Journal of Applied …, 2022 - journals.physiology.org
The cardiovascular benefits of regular exercise are unequivocal, yet patients with type 2
diabetes respond poorly to exercise due to a reduced cardiac reserve. The contractile …
diabetes respond poorly to exercise due to a reduced cardiac reserve. The contractile …
[HTML][HTML] Sarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart
Systolic and diastolic dysfunction in diabetes have frequently been associated with
abnormal calcium (Ca2+) regulation. However, there is emerging evidence that Ca2+ …
abnormal calcium (Ca2+) regulation. However, there is emerging evidence that Ca2+ …
Cannabinoid 2 receptor activation protects against diabetic cardiomyopathy through inhibition of AGE/RAGE-induced oxidative stress, fibrosis, and inflammasome …
HM Hashiesh, S Azimullah, NM MF… - Journal of …, 2024 - jpet.aspetjournals.org
Oxidative stress, fibrosis, and inflammasome activation from AGE-RAGE interaction
contribute to diabetic cardiomyopathy (DCM) formation and progression. Our study revealed …
contribute to diabetic cardiomyopathy (DCM) formation and progression. Our study revealed …
The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament
FM Payne, S Nie, GM Diffee, GT Wilkins… - Physiological …, 2024 - Wiley Online Library
Patients undergoing cardiopulmonary bypass procedures require inotropic support to
improve hemodynamic function and cardiac output. Current inotropes such as dobutamine …
improve hemodynamic function and cardiac output. Current inotropes such as dobutamine …
[引用][C] Yann Huey Ng1, 2, Regis R. Lamberts2, Peter P. Jones2, Ivan A. Sammut3, Gary M. Diffee4
GT Wilkins, JC Baldi1Ε - Scientific Reports, 2022