SVOC exposure indoors: fresh look at dermal pathways

CJ Weschler, WW Nazaroff - Indoor air, 2012 - Wiley Online Library
This paper critically examines indoor exposure to semivolatile organic compounds (SVOCs)
via dermal pathways. First, it demonstrates that–in central tendency–an SVOC's abundance …

Mathematical models of skin permeability: an overview

S Mitragotri, YG Anissimov, AL Bunge… - International journal of …, 2011 - Elsevier
Mathematical models of skin permeability play an important role in various fields including
prediction of transdermal drug delivery and assessment of dermal exposure to industrial …

[HTML][HTML] Molecular size as the main determinant of solute maximum flux across the skin

BM Magnusson, YG Anissimov, SE Cross… - Journal of Investigative …, 2004 - Elsevier
One of the most important determinants of dermatological and systemic penetration after
topical application is the delivery or flux of solutes into or through the skin. The maximum …

Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability

G Ottaviani, S Martel, PA Carrupt - Journal of medicinal chemistry, 2006 - ACS Publications
This work was devoted to the search for new artificial membranes allowing a rapid
evaluation of passive human skin permeation of compounds with a parallel artificial …

Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes

YG Anissimov, OG Jepps, Y Dancik… - Advanced Drug Delivery …, 2013 - Elsevier
Topical delivery to the various regions of the skin and underlying tissues, transdermal drug
delivery and dermal exposure to environmental chemicals are important areas of research …

Quantitative structure-skin permeability relationships

I Tsakovska, I Pajeva, M Al Sharif, P Alov, E Fioravanzo… - Toxicology, 2017 - Elsevier
This paper reviews in silico models currently available for the prediction of skin permeability.
A comprehensive discussion on the developed methods is presented, focusing on …

[HTML][HTML] Evaluating molecular properties involved in transport of small molecules in stratum corneum: A quantitative structure-activity relationship for skin permeability

CP Chen, CC Chen, CW Huang, YC Chang - Molecules, 2018 - mdpi.com
The skin permeability (Kp) defines the rate of a chemical penetrating across the stratum
corneum. This value is widely used to quantitatively describe the transport of molecules in …

Quantitative structure-permeation relationships (QSPeRs) to predict skin permeation: a critical evaluation

S Geinoz, RH Guy, B Testa, PA Carrupt - Pharmaceutical Research, 2004 - Springer
Purpose. Development of reliable mathematical models to predict skin permeability remains
a challenging objective. This article examines some of the existing algorithms and critically …

[HTML][HTML] Effect of drug loading method and drug physicochemical properties on the material and drug release properties of poly (ethylene oxide) hydrogels for …

RSH Wong, K Dodou - Polymers, 2017 - mdpi.com
Novel poly (ethylene oxide)(PEO) hydrogel films were synthesized via UV cross-linking with
pentaerythritol tetra-acrylate (PETRA) as cross-linking agent. The purpose of this work was …

Emerging investigator series: the role of chemical properties in human exposure to environmental chemicals

Z Zhang, S Wang, L Li - Environmental Science: Processes & Impacts, 2021 - pubs.rsc.org
One of the ultimate goals of environmental exposure science is to mechanistically
understand how chemical properties and human behavior interactively determine human …