An individual's major histocompatibility complex (MHC) ancestral haplotype (AH) is the
dearest single determinant of susceptibility to MHC associated immunopathological disease …

Acute graft-versus-host disease (GVHD) afflicts as much as 80% of all patients who receive
an unrelated donor hematopoietic cell transplant (HCT) for the treatment of blood disorders …

Lung transplantation is the treatment option for a variety of end-stage pulmonary diseases.
Posttransplant development of Abs against donor HLA and non-HLA Ags have been …

The human major histocompatibility complex class I chain-related gene A (MICA) is one of
the genes in the HLA class I region of chromosome 6. Unlike HLA classical class I gene …

Allogeneic bone marrow transplantation (BMT) from a genotypically identical family donor is
an accepted therapeutic option for homozygous beta-thalassemia. However, only a minority …

HLA alleles are functionally relevant. Unrelated HCT can be optimized by comprehensive
and precise donor-recipient allele matching. For patients with high-risk diseases who lack …

Although the effects of human leukocyte antigen (HLA) locus matching on clinical outcome
in unrelated hematopoietic stem cell transplantations have been characterized, the biologic …

Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic
hematopoietic cell transplantation. Many genes are presumed to be involved in GVHD, but …

Identification of an unrelated HLA allele-matched hematopoietic stem cell (HSC) donor is a
costly and time-consuming procedure. To improve search logistics, we have limited the …

Since the discovery of human leukocyte antigens (HLAs), the function of major
histocompatibility complex (MHC) gene families in a wide range of diseases have been the …