I. Introduction A FUNCTIONAL relationship between cell growth and the initiation and
progression of events associated with differentiation has been a fundamental question …

We present an overview of Runx involvement in regulatory mechanisms that are requisite for
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …

Objective Osteocalcin has been proposed to be a novel link between bone and energy
metabolism. Previous studies showed its relations to exercise, body fat and glucose …

Osteoblast differentiation is a multistep series of events modulated by an integrated cascade
of gene expression that initially supports proliferation and the sequential expression of …

Although a number of secreted factors have been demonstrated to be bone regulators, none
of these are unique to bone. Using a viral-based signal-trap strategy we have identified a …

1, 25-Dihydroxyvitamin D3 (1, 25-(OH) 2D3) is known to regulate the expression of
neurotrophins [45, 46]. Here, we report that 1, 25-(OH) 2D3 does not influence the …

Publisher Summary This chapter focuses on apoptosis in bone cells. Apoptosis is a form of
individual cell suicide that was originally defined by a series of morphological changes in …

In osteoblast‐like cells in culture, the human osteocalcin gene promoter basal activity is
repressed by glucocorticoids, reflecting the repression of serum osteocalcin concentrations …

The OC box of the rat osteocalcin promoter (nt-99 to-76) is the principal proximal regulatory
element contributing to both tissue-specific and developmental control of osteocalcin gene …

Publisher Summary This chapter describes the regulated expression of the bone-specific
osteocalcin gene by vitamins and hormones. Expression of the bone-specific osteocalcin …