Background: Preterm infants are at high risk for Encephalopathy of Prematurity and
successive adverse neurodevelopmental outcome. Adequate nutrition is crucial for healthy …

A relationship appears to exist between dysfunction of brain histamine (HA) and various
neuropsychiatric brain disorders. The possible involvement of brain HA in neuropathology …

Preterm brain injury, occurring in approximately 30% of infants born< 32 weeks gestational
age, is associated with an increased risk of neurodevelopmental disorders, such as autism …

A leading cause of preterm birth is the exposure to systemic inflammation (maternal/fetal
infection), which leads to neuroinflammation and white matter injury (WMI). A wide range of …

Microglia of the developing brain have unique functional properties but how their activation
states are regulated is poorly understood. Inflammatory activation of microglia in the still …

Objectives In the premature newborn, perinatal inflammation mediated by microglia
contributes significantly to neurodevelopmental injuries including white matter injury (WMI) …

Adult neurogenesis in hippocampus dentate gyrus (DG) is associated with numerous
neurodegenerative diseases such as aging and Alzheimer's disease (AD). Overactivation of …

Calcium ions are vital for maintaining the physiological and biochemical processes inside
cells. The central nervous system (CNS) is particularly dependent on calcium homeostasis …

Alzheimer's disease (AD) is an age-related neurodegenerative disease, which characterized
by deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, neuronal loss, and …

Abstract The sphingosine 1-phosphate (S1P) receptor 1 (S1P 1) has emerged as a
therapeutic target for the treatment of multiple sclerosis (MS). Fingolimod (FTY720) is the first …