Curcumin in cancer therapy: A novel adjunct for combination chemotherapy with paclitaxel and alleviation of its adverse effects

M Ashrafizadeh, A Zarrabi, F Hashemi, ER Moghadam… - Life sciences, 2020 - Elsevier
Dealing with cancer is of importance due to enhanced incidence rate of this life-threatening
disorder. Chemotherapy is an ideal candidate in overcoming and eradication of cancer. To …

The folate receptor as a rational therapeutic target for personalized cancer treatment

YG Assaraf, CP Leamon, JA Reddy - Drug Resistance Updates, 2014 - Elsevier
Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …

Juno is the egg Izumo receptor and is essential for mammalian fertilization

E Bianchi, B Doe, D Goulding, GJ Wright - Nature, 2014 - nature.com
Fertilization occurs when sperm and egg recognize each other and fuse to form a new,
genetically distinct organism. The molecular basis of sperm–egg recognition is unknown, but …

Structural basis for molecular recognition of folic acid by folate receptors

C Chen, J Ke, XE Zhou, W Yi, JS Brunzelle, J Li… - Nature, 2013 - nature.com
Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …

Microbial metabolic capacity for intestinal folate production and modulation of host folate receptors

MA Engevik, CN Morra, D Röth, K Engevik… - Frontiers in …, 2019 - frontiersin.org
Microbial metabolites, including B complex vitamins contribute to diverse aspects of human
health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin …

Small molecules as cancer targeting ligands: Shifting the paradigm

N Kaur, P Popli, N Tiwary, R Swami - Journal of Controlled Release, 2023 - Elsevier
Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …

Interrogation of folic acid-functionalized nanomedicines: the regulatory roles of plasma proteins reexamined

H Wang, T Ding, J Guan, X Liu, J Wang, P Jin, S Hou… - ACS …, 2020 - ACS Publications
Folic acid (FA) has been extensively exploited to facilitate targeted delivery of
nanomedicines by recognizing the folate receptor-α (FR-α) overexpressed in many human …

Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex

H Aydin, A Sultana, S Li, A Thavalingam, JE Lee - Nature, 2016 - nature.com
Fertilization is an essential biological process in sexual reproduction and comprises a series
of molecular interactions between the sperm and egg,. The fusion of the haploid …

Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization

U Ohto, H Ishida, E Krayukhina, S Uchiyama, N Inoue… - Nature, 2016 - nature.com
Fertilization is a fundamental process in sexual reproduction, creating a new individual
through the combination of male and female gametes,,,. The IZUMO1 sperm membrane …

Folate-conjugated nanovehicles: Strategies for cancer therapy

B Farran, RC Montenegro, P Kasa, E Pavitra… - Materials Science and …, 2020 - Elsevier
Cancer theranostics represents a strategy that aims at combining diagnosis with therapy
through the simultaneous imaging and targeted delivery of therapeutics to cancer cells …