Curcumin in cancer therapy: A novel adjunct for combination chemotherapy with paclitaxel and alleviation of its adverse effects
Dealing with cancer is of importance due to enhanced incidence rate of this life-threatening
disorder. Chemotherapy is an ideal candidate in overcoming and eradication of cancer. To …
disorder. Chemotherapy is an ideal candidate in overcoming and eradication of cancer. To …
The folate receptor as a rational therapeutic target for personalized cancer treatment
Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
Juno is the egg Izumo receptor and is essential for mammalian fertilization
E Bianchi, B Doe, D Goulding, GJ Wright - Nature, 2014 - nature.com
Fertilization occurs when sperm and egg recognize each other and fuse to form a new,
genetically distinct organism. The molecular basis of sperm–egg recognition is unknown, but …
genetically distinct organism. The molecular basis of sperm–egg recognition is unknown, but …
Structural basis for molecular recognition of folic acid by folate receptors
Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …
Microbial metabolic capacity for intestinal folate production and modulation of host folate receptors
Microbial metabolites, including B complex vitamins contribute to diverse aspects of human
health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin …
health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin …
Small molecules as cancer targeting ligands: Shifting the paradigm
Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
Interrogation of folic acid-functionalized nanomedicines: the regulatory roles of plasma proteins reexamined
H Wang, T Ding, J Guan, X Liu, J Wang, P Jin, S Hou… - ACS …, 2020 - ACS Publications
Folic acid (FA) has been extensively exploited to facilitate targeted delivery of
nanomedicines by recognizing the folate receptor-α (FR-α) overexpressed in many human …
nanomedicines by recognizing the folate receptor-α (FR-α) overexpressed in many human …
Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex
Fertilization is an essential biological process in sexual reproduction and comprises a series
of molecular interactions between the sperm and egg,. The fusion of the haploid …
of molecular interactions between the sperm and egg,. The fusion of the haploid …
Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization
Fertilization is a fundamental process in sexual reproduction, creating a new individual
through the combination of male and female gametes,,,. The IZUMO1 sperm membrane …
through the combination of male and female gametes,,,. The IZUMO1 sperm membrane …
Folate-conjugated nanovehicles: Strategies for cancer therapy
Cancer theranostics represents a strategy that aims at combining diagnosis with therapy
through the simultaneous imaging and targeted delivery of therapeutics to cancer cells …
through the simultaneous imaging and targeted delivery of therapeutics to cancer cells …