Inflammation plays a prominent role in the development of atherosclerosis and other
cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular …

Among statin-treated patients, inflammation assessed by means of high-sensitivity C-
reactive protein (hsCRP) is a more powerful determinant of cardiovascular death and all …

The international consortium detected a full-length transcript of 3· 7 kb encoding a protein
consisting of 781 aminoacids. This protein product was termed “pyrin”, indicating its relation …

The management of cancer involves procedures, which include surgery, radiotherapy and
chemotherapy. Development of chemoresistance is a persistent problem during the …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

We have previously shown that absence of the mouse mdr1a (also called mdr3) P-
glycoprotein in mdr1a (-/-)" knockout" mice has a profound effect on the tissue distribution …

The mdr1-type P-glycoproteins (P-gps) confer multidrug resistance to cancer cells by active
extrusion of a wide range of drugs from the cell. To study their physiological roles, we have …

P-glycoprotein is the product of the ABCB1 [also known as multidrug resistance 1 (MDR1)]
gene. It translocates a broad variety of xenobiotics out of cells. P-glycoprotein was first …

The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …