Colchicine in cardiovascular disease: in-depth review
SG Deftereos, FJ Beerkens, B Shah, G Giannopoulos… - Circulation, 2022 - Am Heart Assoc
Inflammation plays a prominent role in the development of atherosclerosis and other
cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular …
cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular …
Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease: JACC Review Topic of the Week
Among statin-treated patients, inflammation assessed by means of high-sensitivity C-
reactive protein (hsCRP) is a more powerful determinant of cardiovascular death and all …
reactive protein (hsCRP) is a more powerful determinant of cardiovascular death and all …
Familial mediterranean fever
E Ben-Chetrit, M Levy - The Lancet, 1998 - thelancet.com
The international consortium detected a full-length transcript of 3· 7 kb encoding a protein
consisting of 781 aminoacids. This protein product was termed “pyrin”, indicating its relation …
consisting of 781 aminoacids. This protein product was termed “pyrin”, indicating its relation …
Mechanisms of drug resistance in cancer chemotherapy
YA Luqmani - Medical principles and practice, 2005 - karger.com
The management of cancer involves procedures, which include surgery, radiotherapy and
chemotherapy. Development of chemoresistance is a persistent problem during the …
chemotherapy. Development of chemoresistance is a persistent problem during the …
Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
SF Zhou - Xenobiotica, 2008 - Taylor & Francis
1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
Polymorphisms in Human MDR1 (P‐glycoprotein): Recent Advances and Clinical Relevance
C Marzolini, E Paus, T Buclin… - Clinical Pharmacology & …, 2004 - Wiley Online Library
Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …
Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.
AH Schinkel, E Wagenaar… - The Journal of …, 1995 - Am Soc Clin Investig
We have previously shown that absence of the mouse mdr1a (also called mdr3) P-
glycoprotein in mdr1a (-/-)" knockout" mice has a profound effect on the tissue distribution …
glycoprotein in mdr1a (-/-)" knockout" mice has a profound effect on the tissue distribution …
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
AH Schinkel, U Mayer, E Wagenaar… - Proceedings of the …, 1997 - National Acad Sciences
The mdr1-type P-glycoproteins (P-gps) confer multidrug resistance to cancer cells by active
extrusion of a wide range of drugs from the cell. To study their physiological roles, we have …
extrusion of a wide range of drugs from the cell. To study their physiological roles, we have …
Importance of P-glycoprotein at blood–tissue barriers
MF Fromm - Trends in pharmacological sciences, 2004 - cell.com
P-glycoprotein is the product of the ABCB1 [also known as multidrug resistance 1 (MDR1)]
gene. It translocates a broad variety of xenobiotics out of cells. P-glycoprotein was first …
gene. It translocates a broad variety of xenobiotics out of cells. P-glycoprotein was first …
The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation
DA Hesselink, R Bouamar, L Elens… - Clinical …, 2014 - Springer
The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …
after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has …