Endocannabinoids were implicated in a variety of pathological conditions including anxiety
and are considered promising new targets for anxiolytic drug development. The optimism …

Rationale Exposure to traumatic events can lead to alterations in social and anxiety-related
behaviors. Emerging evidence suggests that peripheral host-defense processes are …

Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid
and individual differences in response to stress suggest resilient and susceptible …

Fatty acid amide hydrolase (FAAH) is an enzyme that degrades anandamide, an
endocannabinoid that modulates mesolimbic dopamine release and, consequently …

Circulating monocytes participate in pain chronification but the molecular events that cause
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …

People with sickle cell disease (SCD) often experience chronic pain as well as
unpredictable episodes of acute pain, which significantly affects their quality of life and life …

Over the past decade, the idea of targeting the endocannabinoid system to treat anxiety
disorders has received increasing attention. Previous studies focused more on developing …

Traumatic experiences result in the development of posttraumatic stress disorder (PTSD) in
10-25% of exposed individuals. While human clinical studies suggest that susceptibility is …