Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
A retrospect study on thiazole derivatives as the potential antidiabetic agents in drug discovery and developments
Background: Heterocycles containing thiazole, a moiety with sulfur and nitrogen is a core
structure which is found in a number of biologically active compounds. The thiazole ring is …
structure which is found in a number of biologically active compounds. The thiazole ring is …
Derivatives of pyridine and thiazole hybrid: Synthesis, DFT, biological evaluation via antimicrobial and DNA cleavage activity
A novel series of the 2-pyridine substituted 3a-e and 4-pyridine substituted 4a-e thiazole
derivatives were synthesized, characterized, and evaluated for the biological activity …
derivatives were synthesized, characterized, and evaluated for the biological activity …
Novel hybrids of benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone: Synthesis, in silico ADME study, molecular docking and in vivo anti-diabetic assessment
A series of new benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone hybrid analogs (Tz1-
Tz28) were synthesized in search of potential anti-diabetic agents. Molecular docking study …
Tz28) were synthesized in search of potential anti-diabetic agents. Molecular docking study …
Synthesis, characterization, α-glucosidase inhibition and molecular modeling studies of some pyrazoline-1H-1, 2, 3-triazole hybrids
A series of molecular hybrids based on pyrazoline and 1, 2, 3-triazole pharmacophores
were designed and synthesized as antidiabetic agents. The structures of all the derivatives …
were designed and synthesized as antidiabetic agents. The structures of all the derivatives …
Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor
In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
Synthesis of novel 5-(2, 5-bis (2, 2, 2-trifluoroethoxy) phenyl)-1, 3, 4-oxadiazole-2-thiol derivatives as potential glucosidase inhibitors
Background A hybrid molecule of different biologically active substances can improve affinity
and efficiency compared to a standard drug. Hence based on this fact, we predict that a …
and efficiency compared to a standard drug. Hence based on this fact, we predict that a …
Synthesis, molecular modelling studies and ADME prediction of benzothiazole clubbed oxadiazole-Mannich bases, and evaluation of their anti-diabetic activity …
A small library of new benzothiazole clubbed oxadiazole-Mannich bases (M-1 to M-22) were
synthesized and characterized by IR, NMR, Mass and Elemental analysis results. Molecular …
synthesized and characterized by IR, NMR, Mass and Elemental analysis results. Molecular …
Low-dose pulsatile interleukin-6 as a treatment option for diabetic peripheral neuropathy
AA Cox, Y Sagot, G Hedou, C Grek, T Wilkes… - Frontiers in …, 2017 - frontiersin.org
Diabetic peripheral neuropathy (DPN) remains one of the most common and serious
complications of diabetes. Currently, pharmacological agents are limited to treating the pain …
complications of diabetes. Currently, pharmacological agents are limited to treating the pain …
Recent Studies of Nitrogen and Sulfur Containing Heterocyclic Analogues as Novel Antidiabetic Agents: A Review
S Gharge, SG Alegaon - Chemistry & Biodiversity, 2024 - Wiley Online Library
The prevalence of diabetes mellitus is on the rise, which demands the identification of novel
antidiabetic drugs. There is a need for safer and more effective alternatives because the …
antidiabetic drugs. There is a need for safer and more effective alternatives because the …