Light has profoundly influenced the evolution of life on earth. As widely appreciated, light
enables us to generate images of our environment. However, light—through intrinsically …

It has been established that 4.4 to 20% of the general population suffers from a major
depressive disorder (MDD), which is frequently associated with a dysregulation of normal …

Inflammation may be defined as the innate response to harmful stimuli such as pathogens,
injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic …

Ageing leads to a functional deterioration of many brain systems, including the circadian
clock—an internal time-keeping system that generates∼ 24-hour rhythms in physiology and …

The most common mood disorders are major depressive disorders and bipolar disorders
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …

The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …

Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity
occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including …

Melatonin, an endogenous signal of darkness, is an important component of the body's
internal time-keeping system. As such it regulates major physiological processes including …

Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

For many years, researchers have suggested that abnormalities in circadian rhythms may
underlie the development of mood disorders such as bipolar disorder (BPD), major …