The hippocampal system is critical for storage and retrieval of declarative memories,
including memories for locations and events that take place at those locations. Spatial …

Changing the strength of connections between neurons is widely assumed to be the
mechanism by which memory traces are encoded and stored in the central nervous system …

Hippocampal place cells support reward-related spatial memories by forming a cognitive
map that over-represents reward locations. The strength of these memories is modulated by …

One of the grand challenges in neuroscience is to comprehend neural computation in the
association cortices, the parts of the cortex that have shown the largest expansion and …

Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary
model by which to study the cellular and molecular basis of memory. Calcium/calmodulin …

Using Ca2+ imaging in freely behaving mice that repeatedly explored a familiar
environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place …

† Veterans Affairs Medical Center memory, attention, perception, and voluntary action. The
development of simple experimental methods for San Diego, California 92161 and …

Identifying the scope and nature of memory processing by the hippocampus has proved a
formidable challenge. The major initial insights came from studies of amnesia in human …

Intracranial recordings in subjects suffering from intractable epilepsy—made during their
evaluation for an eventual surgical removal of the epileptic focus—have allowed the …

Animals can navigate vast distances and often display behaviours or activities that indicate a
detailed, internal spatial representation of their surrounding environment or a 'cognitive …