In all cells, proteins are continuously synthesized and degraded to maintain protein
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …

Human physiology and pathology arise from the coordinated interactions of diverse single
cells. However, analyzing single cells has been limited by the low sensitivity and throughput …

Aggressive and metastatic cancers show enhanced metabolic plasticity, but the precise
underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA …

The papain-like protease PLpro is an essential coronavirus enzyme that is required for
processing viral polyproteins to generate a functional replicase complex and enable viral …

A new coronavirus was recently discovered and named severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). Infection with SARS-CoV-2 in humans causes coronavirus …

Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

With increased life expectancy, age-associated cognitive decline becomes a growing
concern, even in the absence of recognizable neurodegenerative disease. The integrated …

Mitophagy is essential to maintain mitochondrial function and prevent diseases. It activates
upon mitochondria depolarization, which causes PINK1 stabilization on the mitochondrial …

Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current
coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration …

SARS-CoV-2 infections are rapidly spreading around the globe. The rapid development of
therapies is of major importance. However, our lack of understanding of the molecular …