The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …

Monoclonal antibodies (mAbs) have revolutionized the treatment of several human
diseases, including cancer and autoimmunity and inflammatory conditions, and represent a …

Seasonal influenza viruses constantly change through antigenic drift and the emergence of
pandemic influenza viruses through antigenic shift is unpredictable. Conventional influenza …

The ability for viruses to mutate and evade the human immune system and cause infection,
called viral escape, remains an obstacle to antiviral and vaccine development …

The adaptive immune response to influenza virus infection is multifaceted and complex,
involving antibody and cellular responses at both systemic and mucosal levels. Immune …

SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging
vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS …

H5 influenza is considered a potential pandemic threat. Recently, H5 viruses belonging to
clade 2.3. 4.4 b have caused large outbreaks in avian and multiple nonhuman mammalian …

Abstract Background Influenza viruses (IVs) have become increasingly resistant to antiviral
drugs that target neuraminidase and matrix protein 2 due to gene mutations that alter their …

Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a
result, preexisting influenza-specific memory B cells can dominate the response after …

SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging
vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant …