Melatonin in cancer treatment: current knowledge and future opportunities

WH Talib, AR Alsayed, A Abuawad, S Daoud… - Molecules, 2021 - mdpi.com
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

Oral submucous fibrosis: a review on biomarkers, pathogenic mechanisms, and treatments

YW Shen, YH Shih, LJ Fuh, TM Shieh - International journal of molecular …, 2020 - mdpi.com
Oral submucous fibrosis (OSF) is a collagen deposition disorder that affects a patient's oral
function and quality of life. It may also potentially transform into malignancy. This review …

Use of melatonin in cancer treatment: where are we?

L Wang, C Wang, WS Choi - International journal of molecular sciences, 2022 - mdpi.com
Cancer represents a large group of diseases accounting for nearly 10 million deaths each
year. Various treatment strategies, including surgical resection combined with …

New insights into how melatonin ameliorates bisphenol A-induced colon damage: Inhibition of NADPH oxidase

Y Yao, W Zhu, D Han, X Shi, S Xu - Journal of Agricultural and …, 2023 - ACS Publications
Bisphenol A (BPA) is an endocrine disruptor, widely employed, and detected in many
consumer products and food items. Oral intake poses a great threat to intestinal health …

Genetic toxicology and toxicokinetics of arecoline and related areca nut compounds: an updated review

NG Oliveira, DL Ramos, RJ Dinis-Oliveira - Archives of toxicology, 2021 - Springer
Areca nut (AN) is consumed by more than 600 million of individuals, particularly in some
regions of South Asia, East Africa, and tropical Pacific, being classified as carcinogenic to …

Caffeic acid phenethyl ester and caffeamide derivatives suppress oral squamous cell carcinoma cells

YH Shih, CC Chen, YH Kuo, LJ Fuh, WC Lan… - International journal of …, 2023 - mdpi.com
Caffeic acid phenethyl ester (CAPE) contains antibiotic and anticancer activities. Therefore,
we aimed to investigate the anticancer properties and mechanisms of CAPE and caffeamide …

Protective and therapeutic potential of melatonin against intestinal diseases: updated review of current data based on molecular mechanisms

S Mehrzadi, M Sheibani, F Koosha… - Expert Review of …, 2023 - Taylor & Francis
Introduction Intestinal diseases, a leading global cause of mortality and morbidity, carry a
substantial socioeconomic burden. Small and large intestines play pivotal roles in …

Melatonin as modulator for sulfur and nitrogen mustard-induced inflammation, oxidative stress and DNA damage: Molecular therapeutics

E Ramos, E Gil-Martín, C De Los Ríos, J Egea… - Antioxidants, 2023 - mdpi.com
Sulfur and nitrogen mustards, bis (2-chloroethyl) sulfide and tertiary bis (2-chloroethyl)
amines, respectively, are vesicant warfare agents with alkylating activity. Moreover …

Melatonin: A smart molecule in the DNA repair system

SM Mir, A Aliarab, G Goodarzi… - Cell Biochemistry …, 2022 - Wiley Online Library
DNA repair is an important pathway for the protection of DNA molecules from destruction.
DNA damage can be produced by oxidative reactive nitrogen or oxygen species, irritation …

Retracted: Arecoline induces epithelial‐mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression

H Ren, G He, Z Lu, Q He, S Li, Z Huang… - Cancer …, 2021 - Wiley Online Library
Arecoline, the main alkaloid of areca nut, is well known for its role in inducing submucosal
fibrosis and oral squamous cell carcinoma (OSCC), however the mechanism remains …