Protein subcellular localization is tightly controlled and intimately linked to protein function in
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

Inhibiting protein function selectively is a major goal of modern drug discovery. Here, we
report a previously understudied benefit of small molecule proteolysis-targeting chimeras …

The development of effective pharmacological inhibitors of multidomain scaffold proteins,
notably transcription factors, is a particularly challenging problem. In part, this is because …

Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with
deletion of chromosome 5q (del (5q)). Here, we demonstrate that lenalidomide induces the …

Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-
limiting event in human gene control. A small number of regulatory factors influence …

Activation of cellular stress response pathways to maintain metabolic homeostasis is
emerging as a critical growth and survival mechanism in many cancers. The pathogenesis of …

Exosomes/small extracellular vesicles (sEVs) can serve as multifactorial mediators of cell-to-
cell communication through their miRNA and protein cargo. Quantitative proteomic analysis …

INTRODUCTION The mammal has evolved an epigenetic mechanism to silence one of two
X chromosomes in the XX female to equalize gene dosages with the XY male. Once …

Intermediary metabolism generates substrates for chromatin modification, enabling the
potential coupling of metabolic and epigenetic states. Here we identify a network linking …