Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …

How glia control axon regeneration remains incompletely understood. Here, we investigate
glial regulation of regenerative ability differences of closely related Drosophila larval …

Neural injury in mammals often leads to persistent functional deficits as spontaneous repair
in the peripheral nervous system (PNS) is often incomplete, while endogenous repair …

Mutations in> 50 genes, including spastin and atlastin, lead to hereditary spastic paraplegia
(HSP). We previously demonstrated that reduction of spastin leads to a deficit in axon …

Decoding how tissue properties emerge across multiple spatial and temporal scales from
the integration of local signals is a grand challenge in quantitative biology. For example, the …

The development of optogenetics, a family of methods for using light to control neural activity
via light-sensitive proteins, has provided a powerful new set of tools for neurobiology. These …

The shape of an individual neuron is linked to its function with axons sending signals to
other cells and dendrites receiving them. Although much is known of the mechanisms for …

Neuroregeneration is a dynamic process synergizing the functional outcomes of multiple
signaling circuits. Channelrhodopsin-based optogenetics shows the feasibility of stimulating …