The DnaA protein has long been considered to play the key role in the initiation of
chromosome replication in modern bacteria. Many questions about this role, however …

Highlights•Metabolism and cell cycle are interconnected at multiple levels in bacteria.•DNA
replication and cytokinesis are processes subject to metabolic regulation.•DNA replication …

Polysaccharide is one of the main active ingredients of Polygonatum kingianum, which has
been proven to regulate the balance of gut microbiota. For the first time, this study focused …

Bacterial morphology is a complex trait that is highly sensitive to changes in the
environment. For heterotrophic organisms, such as Escherichia coli, increases in nutrient …

Background In all living organisms, DNA replication is exquisitely regulated in a wide range
of growth conditions to achieve timely and accurate genome duplication prior to cell division …

Bacterial cell proliferation is highly efficient, both because bacteria grow fast and multiply
with a low failure rate. This efficiency is underpinned by the robustness of the cell cycle and …

Metabolism and DNA replication are the two most fundamental biological functions in life.
The catabolic branch of metabolism breaks down nutrients to produce energy and …

DNA replication is coupled to growth by an unknown mechanism. Here, we investigated this
coupling by analyzing growth and replication in 15 mutants of central carbon metabolism …

A direct link between DNA replication regulation and central carbon metabolism (CCM) has
been previously demonstrated in Bacillus subtilis and Escherichia coli, as effects of certain …

RecBCD helicase/nuclease supports replication fork progress via recombinational repair or
linear DNA degradation, explaining recBC mutant synthetic lethality with replication …