Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

Malignant brain tumors strike deep into the psyche of those receiving and those delivering
the diagnosis. Malignant gliomas, the most common subtype of primary brain tumors, are …

Little progress has been made in the treatment of gliomas during the past 25 years. One
reason is our poor understanding of the cell of origin in these tumors and of the mechanisms …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Malignant glioma remains incurable despite tremendous advancement in basic research
and clinical practice. The identification of the cell (s) of origin should provide deep insights …

We present evidence that some low-grade oligodendrogliomas may be comprised of
proliferating glial progenitor cells that are blocked in their ability to differentiate, whereas …

For decades, it has been known that gliomas follow a non-random spatial distribution,
appearing more often in some brain regions (eg the insula) compared to others (eg the …

Glioma remains incurable despite great advancements in medicine. Targeting the cell of
origin for gliomas could bring great hope for patients. However, as a collection of diverse …

Astrocytomas, oligodendrogliomas, and oligoastrocytomas, collectively referred to as diffuse
gliomas, are the most common primary brain tumors. These tumors are classified by …

OBJECTIVE: Several studies have shown that human gliomas contain a small population of
cells with stem cell-like features. It has been proposed that these “cancer stem cells” may be …