Methamphetamine (METH) is an illicit psychostimulant that is abused throughout the world.
METH addiction is also a major public health concern and the abuse of large doses of the …

With aging, the nervous system gradually undergoes degeneration. Increased oxidative
stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

There are several pathologies, syndromes, and physiological processes in which autophagy
is involved. This process of self‐digestion that cells trigger as a survival mechanism is …

Brain aging is linked to certain types of neurodegenerative diseases and identifying new
therapeutic targets has become critical. Melatonin, a pineal hormone, associates with …

Depression is characterized by sadness, purposelessness, irritability, and impaired body
functions. Depression causes severe symptoms for several weeks, and dysthymia, which …

Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage
inflicted is usually a consequence of the ability of these toxic agents to induce free radical …

As a clonal disease of hematopoietic stem cells (HSCs), the etiology and pathogenesis of
leukemia is not fully understood. Recent studies suggest that cellular homeostasis plays an …

Many neurodegenerative diseases exhibit protein accumulation and increased oxidative
stress. Therapeutic strategies include clearing aggregate-prone proteins by enhancing …

Melatonin has been proven to possess neuroprotection property against various
neurological diseases by decreasing cerebral oxidative stress and inhibiting inflammatory …