Leptomeningeal carcinomatosis (LC) is defined as infiltration of the leptomeninges by
metastatic carcinoma, a relatively uncommon but devastating complication of many …

Challenges in obtaining tissue specimens from patients with brain tumours limit the
diagnosis and molecular characterisation and impair the development of better therapeutic …

These EANO–ESMO joint recommendations for the diagnosis and treatment of
leptomeningeal metastasis (LM) from solid cancers represent the first European guideline …

Simple Summary The optimal treatment and management of patients with brain cancer
depend on the molecular characteristics of their tumour. Since the tumour changes with time …

The breast is one of the common primary sites of brain metastases (BM). Radiotherapy for
BM from breast cancer may include whole brain radiation therapy (WBRT), stereotactic …

Leptomeningeal carcinomatosis (LC) is a rare but challenging manifestation of advanced
breast cancer with a severe impact on morbidity and mortality. We performed a systematic …

Purpose Leptomeningeal disease (LMD) is an advanced metastatic disease presentation
portending a poor prognosis with minimal treatment options. The advent and widespread …

Background: Palliative care consultation during serious life-limiting illness can reduce
symptom burden and improve quality of care. However, quantifying the impact of palliative …

Background Breast cancer (BC) is one of the solid tumors most commonly associated with
leptomeningeal disease (LMD). LMD carries a devastating prognosis; however, disease …

Approximately 50% of patients with advanced human epidermal growth factor 2 (HER2)-
positive breast cancer and triple-negative breast cancer (TNBC) ultimately develop breast …