The classic view portrays Parkinson disease (PD) as a motor disorder resulting from loss of
substantia nigra pars compacta dopaminergic neurons. Multiple studies, however, describe …

Occupational or environmental exposure to manganese (Mn) can lead to the development of
“Manganism,” a neurological condition showing certain motor symptoms similar to …

The pathological process underlying amyotrophic lateral sclerosis (ALS) is associated with
the formation of cytoplasmic inclusions consisting mainly of phosphorylated 43-kDa …

Parkinson's disease (PD) is the second most common neurodegenerative disease. PD
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …

Exosomes are small vesicles released from cells into extracellular space. We have isolated
exosomes from neuroblastoma cells and investigated their influence on the aggregation of α …

Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …

The accumulation and propagation of misfolded α-synuclein (α-Syn) is a central feature of
Parkinson's disease and other synucleinopathies. Molecular compatibility between a fibrillar …

The pollution of heavy metals (HMs) in the environment is a significant global environmental
issue, characterized by its extensive distribution, severe contamination, and profound …

Coenzyme Q10 (CoQ10) is a component of electron transport chain and acts as an
antioxidant. It is also used for preventing neurodegeneration against mitochondrial …

Diagnosis of Parkinson's disease (PD) relies on clinical history and physical examination,
but misdiagnosis is common in early stages. Identification of biomarkers for PD may allow …