Opioid receptors are widely distributed throughout the brain and play an essential role in
modulating aspects of human mood, reward, and well-being. Accumulating evidence …

Animal studies over the past two decades have led to extensive advances in our
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …

The development of functionally distinct catalysts for enantioselective synthesis is a
prominent yet challenging goal of synthetic chemistry. In this work, we report a family of …

Major depressive disorder (MDD) is widely accepted as having a heterogenous
pathophysiology involving a complex mixture of systemic and CNS processes. A …

Alternatives to traditional categorical diagnoses have been proposed to improve the validity
and utility of psychiatric nosology. This paper continues the companion review of an …

Background: Depression is a disease that affects millions of people worldwide, and the
discovery and development of effective and safe antidepressant drugs is one of the …

Selective inhibition of kappa opioid receptors (KORs) is highly anticipated as a
pharmacotherapeutic intervention for substance use disorders and depression. The …

Commonly used pain therapeutics, such as opioid medications, exert dangerous side effects
and lack effectiveness in treating some types of pain. Ketamine is also used to treat pain, but …

Neurobehavioral deficits emerge in nearly 50% of patients following a mild traumatic brain
injury (TBI) and may persist for months. Ketamine is used frequently as an …

Background Approximately 30% of persons with Major Depressive Disorder (MDD)
inadequately respond to conventional antidepressants. Kappa opioid receptor (KOR) …