In the past two decades, biopharmaceuticals have been a breakthrough in improving the
quality of lives of patients with various cancers, autoimmune, genetic disorders etc. With the …

Pandemics and epidemics are continually challenging human beings' health and imposing
major stresses on the societies particularly over the last few decades, when their frequency …

Biopharmaceuticals have established an indisputable presence in the pharmaceutical
pipeline, enabling highly specific new therapies. However, manufacturing, isolating, and …

Mannitol, leucine, and trehalose have been widely used in spray-dried formulations,
especially for inhalation formulations. The individual contribution of these excipients on …

Protein-based therapeutics have revolutionized the pharmaceutical industry and become
vital components in the development of future therapeutics. They offer several advantages …

The oral delivery of biologics such as therapeutic proteins, peptides and oligonucleotides for
the treatment of colon related diseases has been the focus of increasing attention over the …

Background Most biopharmaceuticals are developed in liquid dosage forms that are less
stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an …

Pulsatile drug delivery systems have the potential to improve patient adherence and
therapeutic efficacy by providing a sequence of doses in a single injection. Herein, a novel …

This study examined the effect of buffer salts on the physical stability of spray-dried and
lyophilized formulations of a model protein, bovine serum albumin (BSA). BSA formulations …

Pulmonary delivery of protein-based therapeutics, including antibodies, is a promising
option for treating respiratory diseases. Spray drying is a widely used method for producing …