Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control
gene expression. Like alternative splicing, usage of alternative poly (A) sites allows a single …

Neurons localize mRNAs near synapses where their translation can be regulated by
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …

The transport of mRNAs to distal subcellular compartments is an important component of
spatial gene expression control in neurons. However, the mechanisms that control mRNA …

The localization of mRNAs to subcellular compartments provides a mechanism for
regulating gene expression with exquisite temporal and spatial control. Recent studies …

RNA transport is an important and fundamental event for local protein synthesis, especially
in neurons. RNA is transported as large granules, but little is known about them. Here, we …

Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key protein kinase in neural
plasticity and memory, as have been shown in several studies since the first evidence in …

The brain produces two brain-derived neurotrophic factor (BDNF) transcripts, with either
short or long 3′ untranslated regions (3′ UTRs). The physiological significance of the two …

Intracellular transport is fundamental for neuronal morphogenesis, function and survival.
Many proteins are selectively transported to either axons or dendrites. In addition, some …

Local protein translation in dendrites could be a means for delivering synaptic proteins to
their sites of action, perhaps in a spatially regulated fashion that could contribute to plasticity …