Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …

The nuclear envelope links the cytoskeleton to structural components of the nucleus. It
functions to coordinate nuclear migration and anchorage, organize chromatin, and aid …

Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins,
nesprins and SUN-domain proteins. These complexes have roles in chromatin organization …

Nuclear movement is critical during neurogenesis and neuronal migration, which are
fundamental for mammalian brain development. Although dynein, Lis1, and other …

Muscle disease as a group is characterized by muscle weakness, muscle loss, and impaired
muscle function. Although the phenotype is the same, the underlying cellular pathologies …

It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …

Despite their importance in cell biology, the mechanisms that maintain the nucleus in its
proper position in the cell are not well understood. This is primarily the result of an …

Prior to the pairing and recombination between homologous chromosomes during meiosis,
telomeres attach to the nuclear envelope and form a transient cluster. However, the protein …

Nucleocytoplasmic coupling is mediated by outer nuclear membrane (ONM) nesprin
proteins and inner nuclear membrane Sun proteins. Interactions spanning the perinuclear …