Caseum: a niche for Mycobacterium tuberculosis drug-tolerant persisters
JP Sarathy, V Dartois - Clinical microbiology reviews, 2020 - Am Soc Microbiol
Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …
Statins increase rifampin mycobactericidal effect
LS Lobato, PS Rosa, JS Ferreira… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Mycobacterium leprae and Mycobacterium tuberculosis antimicrobial resistance has been
followed with great concern during the last years, while the need for new drugs able to …
followed with great concern during the last years, while the need for new drugs able to …
Reversible lipid accumulation and associated division arrest of Mycobacterium avium in lipoprotein-induced foamy macrophages may resemble key events during …
I Caire-Brändli, A Papadopoulos, W Malaga… - Infection and …, 2014 - Am Soc Microbiol
During the dormant phase of tuberculosis, Mycobacterium tuberculosis persists in lung
granulomas by residing in foamy macrophages (FM) that contain abundant lipid bodies (LB) …
granulomas by residing in foamy macrophages (FM) that contain abundant lipid bodies (LB) …
The Mycobacterium tuberculosis MmpL11 cell wall lipid transporter is important for biofilm formation, intracellular growth, and nonreplicating persistence
CC Wright, FF Hsu, E Arnett, JL Dunaj… - Infection and …, 2017 - Am Soc Microbiol
The mycobacterial cell wall is crucial to the host-pathogen interface, because it provides a
barrier against antibiotics and the host immune response. In addition, cell wall lipids are …
barrier against antibiotics and the host immune response. In addition, cell wall lipids are …
A novel tool to identify bactericidal compounds against vulnerable targets in drug-tolerant M. tuberculosis found in caseum
Caseous necrosis is a hallmark of tuberculosis (TB) pathology and creates a niche for drug-
tolerant persisters within the host. Cavitary TB and high bacterial burden in caseum require …
tolerant persisters within the host. Cavitary TB and high bacterial burden in caseum require …
Mce1R of Mycobacterium tuberculosis prefers long-chain fatty acids as specific ligands: a computational study
D Maity, D Singh, A Bandhu - Molecular Diversity, 2023 - Springer
The mce1 operon of Mycobacterium tuberculosis, which codes the Mce1 transporter,
facilitates the transport of fatty acids. Fatty acids are one of the major sources for carbon and …
facilitates the transport of fatty acids. Fatty acids are one of the major sources for carbon and …
Untargeted metabolomic analysis reveals the metabolic disturbances and exacerbation of oxidative stress in the cerebral cortex of a BTBR mouse model of Autism
C Cao, Q Li, Y Chen, M Zou, C Sun, X Li… - Journal of Molecular …, 2023 - Springer
The etiology and pathology of autism spectrum disorders (ASDs) are still poorly understood,
which largely limit the treatment and diagnosis of ASDs. Emerging evidence supports that …
which largely limit the treatment and diagnosis of ASDs. Emerging evidence supports that …
Multiscale model of Mycobacterium tuberculosis infection maps metabolite and gene perturbations to granuloma sterilization predictions
Granulomas are a hallmark of tuberculosis. Inside granulomas, the pathogen
Mycobacterium tuberculosis may enter a metabolically inactive state that is less susceptible …
Mycobacterium tuberculosis may enter a metabolically inactive state that is less susceptible …
Establishment of a patient-derived, magnetic levitation-based, three-dimensional spheroid granuloma model for human tuberculosis
Tuberculous granulomas that develop in response to Mycobacterium tuberculosis (M.
tuberculosis) infection are highly dynamic entities shaped by the host immune response and …
tuberculosis) infection are highly dynamic entities shaped by the host immune response and …
Mycobacterium tuberculosis is selectively killed by rifampin and rifapentine in hypoxia at neutral pH
A Iacobino, G Piccaro, F Giannoni… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
The activities of rifampin, rifapentine, bedaquiline, PA-824, clofazimine, nitazoxanide,
isoniazid, amikacin, moxifloxacin, niclosamide, thioridazine, and pyrazinamide were tested …
isoniazid, amikacin, moxifloxacin, niclosamide, thioridazine, and pyrazinamide were tested …